TY - JOUR ID - 159654 TI - Solubility of Lamotrigine in Polyethylene Glycol 400 + 2-Propanol Mixtures at Different Temperatures JO - Physical Chemistry Research JA - PCR LA - en SN - 2322-5521 AU - Sheikhi-Sovari, Atefeh AU - Seyfinejad, Behrouz AU - Zhao, Hongkun AU - Rahimpour, Elaheh AU - Jouyban, Abolghasem AD - Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran AD - College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, People’s Republic of China AD - Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AD - Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Faculty of Pharmacy, Near East University, P. O. Box: 99138 Nicosia, North Cyprus, Mersin 10, Turkey Y1 - 2023 PY - 2023 VL - 11 IS - 3 SP - 675 EP - 682 KW - Solubility KW - lamotrigine KW - Cosolvency models KW - Dissolution thermodynamics DO - 10.22036/pcr.2022.356526.2169 N2 - In this study, the shake-flask method was used to determine the solubility of lamotrigine (LTG) in non-aqueous mixtures of polyethylene glycol 400 (PEG 400) and 2-propanol at temperatures of 293.15 to 313.15 K. Five main mathematical models were used to correlate the experimental data. The overall mean relative deviations for these models were less than 18.7 %. In addition, the apparent thermodynamic properties of LTG dissolution were computed. It is found that the LTG dissolution in PEG 400-rich mixtures is more favorable and proceeds entropically. Both experimental and mathematical methods were used to determine the density of LTG-saturated solutions. The results showed that the Jouyban–Acree model could be used to predict the density of LTG saturated solutions in mixtures with a very good approximation (back-calculated MRD% of 0.4). UR - https://www.physchemres.org/article_159654.html L1 - https://www.physchemres.org/article_159654_8d8dff01816153c1b08bc3bc2ffc99de.pdf ER -