Document Type : Regular Article
Authors
1
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, People’s Republic of China
3
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Faculty of Pharmacy, Near East University, P. O. Box: 99138 Nicosia, North Cyprus, Mersin 10, Turkey
10.22036/pcr.2022.356526.2169
Abstract
In this study, the shake-flask method was used to determine the solubility of lamotrigine (LTG) in non-aqueous mixtures of polyethylene glycol 400 (PEG 400) and 2-propanol at temperatures of 293.15 to 313.15 K. Five main mathematical models were used to correlate the experimental data. The overall mean relative deviations for these models were less than 18.7 %. In addition, the apparent thermodynamic properties of LTG dissolution were computed. It is found that the LTG dissolution in PEG 400-rich mixtures is more favorable and proceeds entropically. Both experimental and mathematical methods were used to determine the density of LTG-saturated solutions. The results showed that the Jouyban–Acree model could be used to predict the density of LTG saturated solutions in mixtures with a very good approximation (back-calculated MRD% of 0.4).
Graphical Abstract
Keywords
)
)