How to Change the Redox Potential of Guanine?

Pakiari, Ali Haidar; Dehghanpisheh, Elham; Haghighi, Behzad

doi:10.22036/pcr.2015.11247

How to Change the Redox Potential of Guanine?

Document Type : Regular Article

Authors

Ali Haidar Pakiari ¹

Elham Dehghanpisheh ²

Behzad Haghighi ³

¹ Shiraz University

² Shiraz University, Chemistry Department.

³ Chemistry Dept. Shiraz University

https://doi.org/10.22036/pcr.2015.11247

Abstract

Due to some important applications of guanine electrode in scientific and technology research such as electro-chemical DNA based biosensors, and a problem of high redox potential of guanine (0.81 V), our research study concentrates on reducing guanine redox potential by substituting Cu, Ag, Au, CH₃, C₂H₅ and Cl on sites of 1, 2 and 9 of guanine. A 5.0% reduction of redox potential for 9-Ag-guanine was the sign of favorable result. In order to have further lower potential, sliver clusters (Ag₂andAg₃) were used. The obtained percentages of reduction of potentials were 53.6% and 36.8% for 9-Ag₂and 9-Ag₃-guanine, respectively. In this research, Gaussian 09 was used and DFT was applied with long-range corrected xc-functional (LC-BLYP).

Graphical Abstract