Study of some Thermodynamic Properties of Vitamin B3 in Aqueous Deep Eutectic Solvent Solutions at T = (288.15 to 318.15) K

Mokhtarpour, Masumeh; Shekaari, Hemayat; Hassanpour Bourkhili, Sahar; Fakhraei, Mina; Nourizadeh, Fatemeh; Afkari, Ramin; Faraji, Saeid

doi:10.22036/pcr.2024.419623.2430

Study of some Thermodynamic Properties of Vitamin B3 in Aqueous Deep Eutectic Solvent Solutions at T = (288.15 to 318.15) K

Document Type : Regular Article

Authors

Masumeh Mokhtarpour

Hemayat Shekaari

Sahar Hassanpour Bourkhili

Mina Fakhraei

Fatemeh Nourizadeh

Ramin Afkari

Saeid Faraji

Department of Physical Chemistry, University of Tabriz, Tabriz, Iran

https://doi.org/10.22036/pcr.2024.419623.2430

Abstract

Deep eutectic solvents (DESs), known for their eco-friendliness and innovative qualities, have shown promise for use in drug systems. This study aims to investigate experimentally some thermodynamic properties of solutions formed by vitamin B3 in aqueous deep eutectic solvent by the measurements of the density and speed of sound (accuracy in density and speed of sound measurements with values of 0.05 kg·m⁻³ and 1 m·s⁻¹). DESs included (choline chloride/malonic acid (ChCl/MA (1:1)), choline chloride/oxalic acid (ChCl/OA (1:1)), choline chloride/ethylene glycol (ChCl/EG (1:2)), and choline chloride/glycerol (ChCl/G (1:2)) in aqueous solutions across a temperature range of (288.15 to 318.15) K. By utilizing the Redlich-Meyer equation and correlating apparent molar volume (V) and apparent molar isentropic compressibility (κφ) values, several key parameters including standard partial molar volume ( ), and partial molar isentropic compressibility ( ) were determined. Furthermore, apparent molar isobaric expansion ( ), and Hepler's constant were computed from these derived parameters. Additionally, Hansen solubility parameters were calculated to predict the solubility of the drug within the solvent medium. Overall, the results suggest a substantial interaction between vitamin B3 and the ChCl/MA system.

Graphical Abstract