Fabrication and Characterization of Nanoporous Ag/ZnO/SBA-16: Its Applications as Drug Delivery Systems

Fekri, Mohammad Hossein; Razavimehr, Maryam; Soleymani, Samaneh; Saki, Fatemeh

doi:10.22036/pcr.2024.466280.2548

Fabrication and Characterization of Nanoporous Ag/ZnO/SBA-16: Its Applications as Drug Delivery Systems

Document Type : Regular Article

Authors

Mohammad Hossein Fekri

Maryam Razavimehr

Samaneh Soleymani

Fatemeh Saki

Department of Chemistry, Faculty of Basic Sciences, Ayatollah Boroujerdi University, Boroujerd, Iran

https://doi.org/10.22036/pcr.2024.466280.2548

Abstract

In this research, the Ag/ZnO/SBA-16 was synthesized and used as loading and release of phenobarbital drug. To identify and characterize the properties of Ag/ZnO/SBA-16 nanostructure, several identification methods such as XRD, FTIR, BET, EDX, SEM, and TEM were used. The influence of various parameters was investigated using the RSM methodology, by experimental design (DOE) software. Drug release in three different environments at 37 ℃ including aqueous, acidic, and alkaline was studied. The isotherm and kinetic studies showed that the drug loading process follows the Freundlich isotherm and the Higuchi kinetics model. The thermodynamic study also showed that drug loading on Ag/ZnO/SBA-16 nanocomposite is an exothermic and spontaneous process at low temperatures.

Graphical Abstract