Physical Chemistry Research

Fe3O4/SBA-16-NH2 Nanocomposites: Synthesis, Characterization and Applications as a Phenobarbital Drug Release Systems

Document Type : Regular Article

Authors

Mohammad Hossein Fekri
M. Razavi Mehr
S. Soleymani

Department of Chemistry, Faculty of Basic Sciences, Ayatollah Boroujerdi University, Boroujerd, Iran

https://doi.org/10.22036/pcr.2025.538792.2715
Abstract
In this study, the Fe3O4/NH2-SBA-16 mesostructure was synthesized as nanocarriers for loading and release of phenobarbital drug. To identify and characterize the properties of SBA-16/NH2 and Fe3O4/NH2-SBA-16 nanostructures, several identification methods such as X-Ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), nitrogen adsorption-adsorption isotherm (BET), elemental analysis (EDX), scanning electron microscope (SEM) and transmission electron microscopy (TEM) images were used. The variables including pH, drug concentration, nanocomposite dose, temperature, and contact time on absorption efficiency were studied by the response surface methodology (RSM), and design of experiments (DOE) software. Drug release in three different environments at 37 ℃ including aqueous medium with pH = 7.0, acidic with pH = 4.6, and basic with pH = 7.8 at times of 1, 2, 3, 4, 12, 24, 48, and 72 hours was studied. The data obtained from isotherm determination studies and drug loading kinetics showed that the drug loading process follows the Langmuir isotherm with R2=0.9989 and the quasi-first-order kinetics model with R2=0.9952. The thermodynamic study also showed that the adsorption of the drug on Fe3O4/NH2-SBA-16 nano silicate is an exothermic and spontaneous process at low temperatures.

Graphical Abstract

Fe3O4/SBA-16-NH2 Nanocomposites: Synthesis, Characterization and Applications as a Phenobarbital Drug Release Systems

Keywords

Fe3O4/NH2-SBA-16 nanocomposite
Drug delivery
Design of experiment
Drug release

Subjects

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Physical Chemistry Research
Volume 13, Issue 4
Autumn 2025
Pages 797-816

  • Receive Date 02 August 2025
  • Revise Date 10 October 2025
  • Accept Date 22 October 2025