Electrical Conductivity Studies of 1-Butyl-3-methylimidazolium Salicylate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) in Aqueous Amino Acids Solutions

Shekaari, Hemayat; Mirheydari, Seyyedeh Narjes; Zafarani-Moattar, Mohammed Taghi

doi:10.22036/pcr.2019.155184.1558

Electrical Conductivity Studies of 1-Butyl-3-methylimidazolium Salicylate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) in Aqueous Amino Acids Solutions

Document Type : Regular Article

Authors

Hemayat Shekaari ¹

Seyyedeh Narjes Mirheydari ²

Mohammed Taghi Zafarani-Moattar ²

¹ Physical Chemistry Department, University of Tabriz, Tabriz, Iran

² Department of Physical Chemistry, University of Tabriz, Tabriz, Iran

https://doi.org/10.22036/pcr.2019.155184.1558

Abstract

The molar conductivity data of 1-butyl-3-methylimidazolium salicylate, [BMIm][Sal] as an active pharmaceutical ingredient ionic liquid (API-IL) have been determined in water and aqueous solutions of amino acids, glycine and L-alanine at T= (288.15 to 318.15) K. The molar conductivity data were analyzed by low concentration Chemical Model (lcCM) and limiting molar conductivities ( ), ion association constants "(" "K" _"A" ) and standard Gibbs energies "(∆" "G" _"A" ^"°" ")" of the ion association process were calculated. The obtained values of and decrease with increase in the amino acid concentration. Moreover, the values of increase from glycine to L-alanine solutions due to the stronger solvation of the ions of [BMIm][Sal] by (COO− /NH3+) zwitterionic centers of glycine relative to L-alanine but this trend is vice versa for . The more negative values of "(∆" "G" _"A" ^"°" ")" for [BMIm][Sal] in glycine relative to L-alanine solutions is indicative of the more spontaneously and feasibility of the association process in this amino acid.

Graphical Abstract